The human genome contains around 20,000 genes. Pretty much everything that makes humans so special, and everything that can go wrong in disease, relates to the function and regulation of these 20,000 genes. Our lab is interested in what makes these genes tick. How is each gene regulated so as to be expressed when and where it is needed? Which mutations in the genome lead to pathogenic gene activity? Can we fix altered states of gene regulation and gene function to treat human diseases?
Research in the lab revolves around identifying new high-throughput screening platforms and machine learning algorithmic solutions that tackle the different angles of this overall goal. We are continuing to develop new technologies to answer these fundamental questions.